HPC018  |  Drug Delivery System Capsule Technology

By confining active ingredients of drugs with porous capsule made of silica, it is possible to maximize the effects of the drugs while minimizing the burdens on human body. The technology offers a drug delivery system encapsulation system where all ingredients of the porous capsule, mainly silica, are very stable under acid condition, and having enough durability against digestive enzyme.

Exhibitor : IPBridge,Inc.

HPC025  |  Smart Bandage for Real-Time Wireless Monitoring of Chronic Wounds

Chronic wounds present a significant challenge to modern health care providers worldwide as wounds often bleed randomly and show variations in pH levels as a result of infection. The diagnosis and treatment are challenging as medical staff often rely on physical inspections. This technology offers a low-cost wearable smart bandage that wirelessly detects early signs of wound infection such as bleeding and pH variations beside external pressure on the wound. The bandage strip can remotely send wound progression data and issue early warnings to patients, as well as remote medical staff, regarding the need to change the dressing.  

Exhibitor : King Abdullah University of Science and Technology

HPC032  |  High Quality Silver Quantum Dots

This technology provides high quality quantum dots which are capable of luminescence at wavelengths desired for medical applications. The quantum dots presented herein have dramatically improved quantum yields and comparatively high transfection efficiencies as well, which is again essential for medical applications. These quantum dots also have low toxicity levels which make them favourable candidates for medical applications. This technology offers an effective and cost efficient way of synthesising these quantum dots.

Exhibitor : KOC University

HPC033  |  Smart Hydrogel for Controlled Release Applications

Several smart advanced materials that are used in drug delivery applications, especially in the medical and pharmaceutical industry. A novel pH responsive hydrogel with improved biocompatibility, uniformity in structure for better performance, enhanced swelling properties and gel integrity at both collapsed and swollen states has been invented.  An effective way of synthesizing these materials is also proposed with this technology.

Exhibitor : KOC University

HPC038  |  Bilayer-Synthetic Tissue Substitute with Drug Delivery

Dural defect is a main problem of cerebrospinal fluid (CSF) leakage and leading many complications in neurosurgery. For decades, many of ideal tissue substitutes have been developed but several commercial products are complicated and costly. In addition, they were created from bovine or porcine tissue. The technology offers a bilayer-synthetic tissue substitute fabricated based on the combination of cellulose and polycarprolactone. In rabbit model, the efficacy was determined comparing with autologous graft implantation.  The studies showed no CSF leakage, infections and even enhanced the dural regeneration. In conclusion, this bilayer-synthetic tissue substitute exhibited excellent biocompatibility with enhancing the dural regeneration.

Exhibitor : Mahidol University

HPC042  |  Therapeutic Engineered Human Antibodies against Ebola Viral Disease

Ebolavirus (EBOV) causes a highly contagious Ebola viral disease (EVD) in human and currently there is no effective direct acting anti-EBOV drug as patients received only palliative therapy. The VP40 and VP35 are conserved proteins across Ebolavirus (EBOV) species and the former has several pivotal roles in the virus life cycle while the latter is the EBVO co-polymerase for viral replication and suppression of host immunity. The researchers has produced cell penetrable human single chain antibodies (transbodies) that bound to EBOV VP40 and VP35, likely the first human antibodies that can interfere with the intracellular Ebola virus proteins.

Exhibitor : Mahidol University

HPC043  |  Xeno-free Umbilical Cord Serum for Stem Cell Manipulation for Medical Purposes

Stem cell holds great promise for medical therapies but xeno contamination is an limitation even various xeno-free proteins have been considered to replace animal serum. Human umbilical cord serum (hUCS) is one of the best protein for xeno-free stem cell preparation and the researchers have developed a high quality xeno-free hUCS media for multi-stem cell type manipulation suitable for commercialization. This technology offers a high quality xeno-free stem cell lines generated or cultured with hUCS media of superiority quality in cell proliferation, epigenetic stability immunosuppressive retaining and delaying senescence.

Exhibitor : Mahidol University

HPC045  |  Treatment of Stress Urinary Incontinence using Non-cultured, Autologous, Adipose-Derived Stem Cells

A team of researchers have been developing a novel regenerative treatment for stress urinary incontinence using non-cultured autologous adipose-derived regenerative cells (ADRCs) and their studies have shown good efficacy and safety of this periuretahral injection of ADRCs. They are now planning to conduct a physician-controlled clinical study through the consultation with the Pharmaceuticals and Medical Devices Agency (PMDA), aiming at the coverage of this treatment by the Japanese Health Insurance.

Exhibitor : Nagoya University

HPC063  |  Food, Pharmaceutical and Nutraceutical Processing using Supercritical Carbon Dioxide Technologies

Supercritical Fluid processing presents numerous opportunities for new product development and alternative processing routes for food, pharmaceutical and nutraceutical ingredient market. The most common form of supercritical fluid used in these applications is carbon dioxide. This is due to its easily accessible critical conditions, its non-toxic nature, abundant supply and easy removal from final product. Supercritical carbon dioxide processing can be used in many ways including extraction, sterilization, antisolvent, foaming, impregnation and etc. for food and pharmaceutical products. 

Exhibitor : Newcastle University

HPC078  |  The Magnetoreceptor (MagR) and it’s Applications

Magnetic sensing, or the ability to detect the Earth’s magnetic field (hereafter magnetoreception), is one of the most mysterious animal senses. The notion that animals can detect the Earth’s magnetic field was once ridiculed, but is now well-established fact. This technology offers an identified a magnetic receptor (designated as MagR) in animals as a rod-like protein complex magnetosensor. 

Exhibitor : Peking University

HPC082  |  Novel Chemotherapeutic Agent for Skin Cancer Treatment

Skin cancer is one of the most common forms of cancer and the currently used chemotherapy drugs for skin cancer treatment being non-selective, lead to various side effects. In search of a more effective chemotherapeutic agent, the researchers have developed and patented a therapeutic compound which is highly effective against skin melanoma cell lines and less toxic to normal skin cells. This novel compound is also found to be more potent than the common anticancer drugs carboplatin and 5-fluorourasil in in-vitro studies. Thus, this a therapeutic compound has potential to be developed as a chemotherapeutic agent for skin cancer treatment.

Exhibitor : Republic Polytechnic

HPC083  |  Sustainable Production of Phyto-ingredients using Hairy Root Cultures

Plants and plant-derived ingredients are common and of major importance in the fields of pharmacy, food and cosmetics. The drawback of using plant-based innovative ingredients is that their production is influenced by many factors such as growth conditions, fluctuating yields, large time-scales of plant growth etc. Hairy root cultures of various pharmacologically significant plants present an attractive production platform that can be customized for various applications to reproducibly generate valuable compounds.

Exhibitor : Republic Polytechnic

HPC086  |  Breast Cancer Therapy with Novel Drug Delivery Approach

This nanomedicine based drug delivery approach, provides selective delivery of targeted chemotherapy agents, minimising side effects and developing pharmacokinetic properties, thus improving the quality of life for patients. This technology is targeted for breast cancer treatment: special polymeric carrier and linker, transporting the medicine directly to the tumour. The system can deliver higher amounts and multiple drugs per dose minimising side effects and increasing efficacy, benefiting patients.

Exhibitor : Sehir TTO

HPC096  |  Prolonged Release Ocular Drug Delivery System

The development of sustained ocular drug delivery platforms which are designed to meet the varying specific duration of effects, ranging from weeks to months, is required for therapeutic effect in different ophthalmic conditions. Drug delivery encompasses the various platforms for achieving the sustained drug release effect, and the mode of delivery of the platform. Sustained release systems can encompass a variety of compounds which range from small protein molecules, drugs, antibodies to nucleic acid entities.

Exhibitor : Singapore Health Services

HPC108  |  Engineered Arginine Depleting Enzymes as Multi-potent Anti-cancer Agents

Arginine is an essential amino acid for protein synthesis and the survival of cancer cells. This technology offers a biologic engineered arginine depleting enzyme (ADE) to treat cancer cells which carry a metabolic defect that renders them unable to synthesize arginine internally. The engineered ADE is designed to deplete the external supply of arginine, causing cancer cells to die while leaving normal cells unharmed. It is found that most cancers have a high degree of arginine-dependency and can potentially be treated with engineered ADE.

Exhibitor : The Hong Kong Polytechnic University