A pH Responsive Hybrid Hydrogel and Method of Synthesis

Abstract/Technology Overview

This technology offer is for a smart hydrogel that can be used in controlled drug release applications and an effective way of synthesizing these materials.

Controlled and site-specific delivery of pharmaceuticals is a widely used method in the pharmaceutical industry in recent years and drug delivery is achieved by smart polymers. Currently, used materials still need to be improved since it is quite challenging to match patient needs at proper times and proper sites of the body. Smart materials, in other words, stimuli-responsive materials are commonly employed as controlled release agents. They give a response to environmental changes such as pH and temperature so that they exhibit desirable physicochemical properties depending on their collapsed or swollen states enabling the regulation of the drug release.

Polymeric hydrogels are one of the most commonly used polymers for controlled release applications since they are biocompatible, pH-responsive and able to retain water. Hydrogels to be used in controlled release applications have to be uniform in structure with enhanced swelling properties, they have to be biocompatible and they have to preserve gel integrity whole time.

With this technology, a pH-responsive polymeric hydrogel with enhanced properties is developed.

Technology Features, Specifications and Advantages

This technology is related to two different smart hydrogel materials to be used in drug delivery applications. The hydrogels are namely P(MAA-g-EG) derivatives which are widely used polymers for controlled release applications. These polymers offered in this technology are synthesized via a novel method and the resulting products turned out to have enhanced properties such as enhanced swelling properties thus more effective uptake/release of the active material.

The synthesis method is also advantageous over the ones that are already known since visible light is used to initiate photopolymerization instead of UV light which makes the end product less toxic thus more biocompatible. Less amount of photo-initiator is employed with this method, resulting in a less toxic end-product. The method is also more feasible since the reaction times are much shorter than the already known methods of synthesis.

Potential Applications

These smart materials are designed to be used in Pharmaceutical Industry for controlled drug delivery. These are pH responsive hydrogels with improved biocompatibility, uniformity in structure for better performance, enhanced swelling properties and gel integrity at both collapsed and swollen states. 

Several smart advanced materials that are used in drug delivery applications in pharmaceutical industry is offered with this invention alongside an effective way of synthesizing these materials.

Customer Benefit

• Enhanced efficacy
• Reduced risk profile
• Increased convenience and compliance
• Enhanced swelling properties and gel integrity at both collapsed and swollen states.

Contact Person

Pelin Gundogdu


Koç University

Technology Category
  • Others
  • Healthcare
  • Bio Materials
Technology Status
  • Available for Licensing
Technology Readiness Level
  • TRL 3

Poly(methacrylic acid-grafted-ethylene glycol), controlled release, pH responsive, hydrogel, P(MAA-g-EG)