Technologies

Growth Factor-free Proliferation & Differentiation of Stem Cell


Abstract/Technology Overview

The conventional methods for cultivating stem cells typically require the use of animals and biochemical growth factors. These methods are costly and the stem cells produced are often cancerous. The technology is a method for growing stem cells without the need of animals or biochemical factors. The device, called inorganic sculptured extracellular nanomatrices (iSECnMs), uses nanoscopic structures on its surfaces to stimulate cell growth. The material is biocompatible and low-cost, so the device is well-suited for mass production. The technology could generate stem cells for use in regenerative therapy, as well as treatment for neurodegenerative, chronic and joint diseases.


Technology Features, Specifications and Advantages

Technology features include:

  • High biosafety level
  • Controllable stem cell differentiation
  • Suitable for mass production
  • The cell growth rate of using this technology is more or less than same as the current methods with growth factors

This technology is feasible to be applied on human because:

1. The materials which the iSECnMs are composed of have been well demonstrated to be biocompatible with no toxicity; 

2. The NSC differentiation on the iSECnMs will be operated in vitro


Potential Applications

Areas where the technology can be applied to includes the following: 

  • Research institutions and laboratories to develop stem cell therapy,
  • Clinics and hospitals, and
  • Therapeutic agents to cure some diseases such as Alzheimer's and Parkinson's diseases.

The team has plans to extract patient’s neural stem cells and develop them into therapeutic agent for incurable diseases without worries of unwanted cell mutations.


Customer Benefit

New opportunities for incurable diseases.

OVERVIEW
Technology Owner

Mandy Liu

Company

Hong Kong Baptist University (Knowledge Transfer Office)

Technology Category
  • Medical Devices
  • Pharmaceuticals & Therapeutics
  • Biotech Research Reagents & Tools
Technology Status
  • Licensed but Available
Technology Readiness Level
  • TRL 4
Keywords

cultivate stem cells, stem cell differentiation, stimulate cell growth, free growth factor