Technologies

A Product for Preventing and Recovering Oxidative Damage to Living Cells


Abstract/Technology Overview

Oxidative stress is thought to be involved in the development of many diseases and pathological conditions such as cancer, neurodegenerative diseases, cardiovascular diseases and aging.

Quercetin is an antioxidant that belongs to a group of plant pigments called flavonoids. Flavonoids give many fruits, flowers, and vegetables their colors. Quercetin scavenges particles, known as free radicals, in the body which damage cell membranes, tamper with DNA, and even cause cell death. Antioxidants can neutralize free radicals.

This technology utilizes the antioxidant features of the quercetin by loading it to a nanoparticle to increase the penetration level of the designated active ingredient into the cell to overcome oxidative stress.


Technology Features, Specifications and Advantages

The aim of this technology is to maximize the antioxidant effect of quercetin for prevention or recovery of the oxidative stress in living cells. Another aim is to improve quercetin penetration into cells.

With this novel technology, quercetin is used as an antioxidant which is loaded onto titanium dioxide (TiO2) nanoparticles for preventing and recovering oxidative damage in living cells. Using TiO2 nanoparticle increases quercetin penetration into the cell while retaining high biosafety, antibacterial and inert properties features. The encapsulated TiO2 nanoparticle also allows for surface modification before loading quercetin. This way, the efficiency of the invention can be increased because the nanoparticle has a higher adhesive surface which allows for more antioxidant molecules to adhered to. 


Potential Applications

Potential Applications:

Quercetin loaded TiO2 nanoparticles can be utilized in several areas and products such as;

  • Dermocosmetics; anti-aging skin care, wound healing, sun care.
  • Medicine; chemotherapeutics in oncology, remedy of skin disorder such as psoriasis or atopic dermatitis in dermatology, as an anti-inflammatory in autoimmune and cardiovascular diseases
  • Pharmacy; antioxidant supplementary


Customer Benefit

  • Ensure safety against to toxicity
  • More capacity for loading quercetin

OVERVIEW
Contact Person

Can Kartoglu

Organisation

Sabanci University

Technology Category
  • Healthcare
  • Bio Materials
  • Nano Materials
  • Personal Care
Technology Status
  • Available for Licensing
Technology Readiness Level
  • TRL 5
Keywords

antioxidant effect, quercetin, recovery of the oxidative stress, nanoparticles, anti-aging skin care, sun care, antioxidant supplementary