Tissue Inducing Biomaterials for Bone Regeneration

Abstract/Technology Overview

A series of biomaterials were invented, which have the ability to induce regeneration or formation of bone and cartilage, as well as the development of a new generation of synthetic bone, namely osteoinductive synthetic bone. The proposed theory of “tissue inducing biomaterials”, i.e. the induction of regeneration or formation of tissue or organ through optimization on the non-living biomaterial formulation, leads to a new approach of biomaterial development.

Technology Features, Specifications and Advantages

Pioneered in research and development of bioactive hydroxyapatite (HA) synthetic bone and coating, the team developed the first HA-coated dental implant and artificial hip joint in China. The invented synthetic bone was approved by the China Food and Drug Administration (CFDA) with medical device registration certificates issued. The invention has been  widely applied in clinical practice with beneficial therapeutic effect. More than 20 product series and 200 types of the products have been used in over 1000 hospitals. The coating technology is applied in most companies of artificial hip joints in China, including some foreign-owned companies.

The work has been recognized globally. Prof. Zhang, the inventor, was elected as a foreign member of the U.S. National Academy of Engineering by his “contributions to musculoskeletal medical therapies and biomaterial product development”. The term “tissue inducing biomaterials” was listed in the “Definition of Biomaterials for the Twenty-First Century” as an emerging concept.


Potential Applications

HA has been proven in clinical use. It has good biocompatibility in bone contact as its chemical composition is similar to that of bone material. HA has enormous use in biomedical applications including bone tissue regeneration and cell proliferation. In bone tissue engineering it can be applied as filling material for bone defects and augmentation, artificial bone graft material in prosthesis revision surgery and dental implants.


Technology Owner

Macy Huen


International Strategic Technology Alliance (ISTA)

Technology Category
  • Medical Devices
  • Bio Materials
Technology Status
  • Available for Licensing
Technology Readiness Level
  • TRL 9

Bone regeneration, Biomaterials, Synthetic bone, Tissue inducing biomaterials