Blood clotting is perennially associated with hemolysis and platelet activation in medical devices (such as the centrifugal and axial blood pumps) due to fast moving parts or high flow velocities. Fast moving parts or high flow velocity impart a large shear stress on blood, distorting and damaging blood cells and activating platelets. Hemolysis can lead to systemic inflammation and organ failure, breakaway clot pieces can cause thromboembolism and tissue damage, and clot formation on devices can lead to device failure. To prevent hemolysis and reduce blood damage, blood-transporting devices require a durable, superhydrophobic coating.
Superhydrophobic coating by state-of-art methods such as spray coating is very thin and can be easily abraded away. Moreover, the top surface layer of the bulk material is not superhydrophobic so it has to be removed to expose the inner super hydrophobic material.
To overcome these limitations, NUS researchers have invented a method to prepare a novel material that can be customized into various 3D geometries and provide a durable, superhydrophobic, blood-repellent and drag-reduction function to the blood-transporting devices.
Technology Features, Specifications and Advantages
This unique method can produce a superhydrophobic coating with the following desirable features:
- Highly durable
- Superhydrophobic as prepared
- Customizable into complex 3D geometries
- Blood repellent
This technology is initially targeting the blood pump market, typically the flexible roller pump tubes for cardiopulmonary bypass, and the centrifugal pumps.
This method of coating has been tested on rigid polymer/plastic and rubber and may also be used on metals. Additional markets can be pursued wherever hydrophobic coating is used:
- Flexible electronics
- Building and construction