Technologies

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Non-invasive Glucose Monitoring

Technology Overview

The global diabetes prevalence is estimated to be 9.3% in 2019 and is expected to rise to 10.2% by 2030 and 10.9% by 2045. Although there is no cure for diabetes, regular blood glucose monitoring and appropriate medication can control the symptoms.

Electrochemical glucose meters are accepted as being the most accurate and reliable glucose measurement devices. However, they are invasive and patients need to take three to six measurements daily. As a result, their nervous system may be damaged due to long-term usage.

There are a number of proposed approaches for non-invasive glucose monitoring, mainly based on optical, transdermal and electrochemical techniques. Due to the nature of these technologies, the proposed approaches are not suitable for continuous monitoring.

To address the problem, our proposed solution is a wearable sensor that makes use of transmission line implemented using a microstrip working at microwave frequencies to measure blood glucose non-invasively and continuously. We are looking for licensees to commercialise this technology.

Technology Features, Specifications and Advantages

This technology is developed based on the fact that the change of the glucose level in blood alters the electrical properties (permittivity and conductivity) of the tissues at the target site

The technology is realized by having a microstrip line (MLIN) built around a finger with the finger serves as the substrate of the MLIN. Signal is input from the tip of the finger. The signal line is on one side of the finger, and the ground plane is on the other side. The return loss of the microstrip is then measured to determine the glucose concentrations.

In our proposed approach, the sensitivity is increased significantly by

  • the dense field between the transmission line and the ground plane for sensing; and
  • the patterned transmission line and patterned ground plane.

The sensor can be worn as a ring, finger stall or bracelet. Other similar products have low penetration depth and their readings are affected by factors such as body temperature and hydration.

Potential Applications

The technology can be used for continuous non-invasive glucose monitoring of diabetic patients.

Customer Benefit

This technology offers a non-invasive alternative method, which could be used to develop a continuous glucose monitoring sensor device with high sensitivity.

OVERVIEW
Contact Person

June Loh

Organisation

Singapore Health Technologies Consortium (HealthTEC)

Technology Category

  • Healthcare
  • Diagnostics, Medical Devices

Technology Readiness Level

Keywords

glucose monitoring, non-invasive, radiofrequency, microwave resonator, microstrip