The company Nanobacterie develops an innovative treatment against cancer using natural iron oxide nano-minerals, called magnetosomes, which are introduced to tumors and heated with various excitation sources (laser, ultrasound, magnetic field). The company Nanobacterie employs 3 researchers, one engineer, 5 PhD students, is located within the campus of the University Paris Saclay. Its aim is to start clinical trials on prostate tumors within the next year.

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Natural Iron Oxide Nano-minerals (Magnetosomes) for Cancer Treatment

Cancer is a leading cause of mortality. Conventional interventions such as surgery, radiotherapy, or chemotherapy present limited efficacy for complete cancer eradication. Current treatments require extensive use of the hospital structure (operating rooms, expensive apparatus, general anesthesia). This calls for new therapies that are less costly, easier to use, do not require general anesthesia and executable outside of hospitals. This is especially relevant during pandemic times when hospitals can become saturated.

The company presents a novel cancer treatment using natural iron oxide nanoparticles termed magnetosomes. These magnetosomes are introduced into tumors and can be heated using energy sources like laser, ultrasound or magnetic field. The heat dissipated from the magnetosomes in turn induces anti-tumor effects.

The patented technology has realized proof of concept of its therapeutic effects on mice bearing prostate tumors and dogs with sarcoma tumors, demonstrating that treatment using heated magnetosomes could lead to full tumor disappearance.

The technology targets the solid tumor market. Solid tumors include tumor mass that is identifiable and treatable by injecting nanoparticles, followed by irradiation. The company has obtained excellent results with glioblastoma, a non-solid tumor characterized with well-identified tumor regions.

With its knowledge and expertise in magnetosome mass production, the company seeks to collaborate with partners with expertise in:

  • Energy sources – Laser, ultrasound, magnetic field, cryotherapy
  • Nanomedicine – Nanoparticles, magnetic nanoparticles for cancer
  • Medical devices – Nanoparticles, magnetic nanoparticles as medical devices for cancer
  • Biocompatibility assessment, regulation, and clinical trials for such medical devices
  • Medical imaging using nanoparticles, magnetic nanoparticles
  • Medical / non-invasive thermometry