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Device For Oxygen Uptake Rate Monitoring

Technology Overview

The COVID-19 virus, which caused a global pandemic, has prompted scientists to look for solutions. One of the most common complications of COVID-19 is pneumonia, after which the patient eventually develops acute respiratory distress syndrome, when oxygen no longer enters the bloodstream and the lungs begin to sink.

The invention is intended to make a preliminary initial assessment of a person's body condition through oxygen uptake and the dynamics of maintaining body biomass viability. It also allows the planning and management of hypoxemia correction measures that would delay or allow for the complete avoidance of intubation and artificial lung ventilation.

In addition to macro-organism monitoring, another use case is helping in maximization of the target product expression when performing aerobic microorganism cultivation in lab scale and industrial bioreactors. A typical installation is a bio-pharmaceutical plant with microbial, mammalian and then stem cells biosynthesis processes, including recombinant proteins, antibodies and other products.

Technology Features, Specifications and Advantages

The invention includes adjustable pressure components that allow non-invasive monitoring of the patient's maximum oxygen solubility. The innovation aims to reduce the "bottle neck" currently created by the lack of pulmonary ventilators when respiratory gas has to be analyzed, for example to noninvasively monitor partial oxygen pressure in arterial blood macro-vessels.

The development of a monitoring device prototype and its control system is relevant because the collected complex data expands the knowledge on how to improve the effectiveness of oxygen therapy in patients. This is done through non-invasive continuous tracking of partial pressure of oxygen in arterial blood by adapting microorganisms bioprocess soft sensor technology for holistic analysis of human respiratory system.

In parallel, the clinical trials on the potential of volatile compounds and oxygen consumption in the diagnosis of ventilated lower respiratory tract infectionshas started to support and research into more clinical use cases for the device.

Oxygen uptake monitor technology allows for noninvasively, based on off-gas analysis, monitor micro-organisms' biomass, target product inside the bioreactor medium and helps to apply optimal control of the bioprocess based on this noninvasive feedback. Results were confirmed by analysis of data from two independent bio-pharmaceutical sites, few papers have been published recently and two patents registered.

Potential Applications

The invention includes the functionality of an oxygen consumption device and examples of its application for the study of the therapeutic effect, the work with microorganisms and the energy characteristics of a macro-organism. Recently a use case with noninvasive continuous estimation of the partial pressure of oxygen in arterial blood has been demonstrated at the preclinical trial. Official clinical trials with a partnering institution have already been started to seek for more use cases in clinical practice.

All oxidative processes in nature, industry and medicine can be analyzed with this device. The invention can be implemented in biotechnology, artificial lung ventilation, intensive care facilities, hyper-baric installation, incubators, noninvasive ventilation, sports or rehabilitation, etc.

Customer Benefit

  • Biopharma: The invention makes it possible to non-invasively increase the reproducibility, specific growth rate and productivity of autonomous bioprocesses to proceed further to continuous and semi-continuous cultivations having no in vitro sensors.
  • Medtech: The invention makes it possible to non-invasively assess the patient's partial pressure of oxygen in the macrovessels. Mostly in medical practice, clinicians use capillary, venous or arterial blood samples to perform pH test for diagnosis of acid- base or gaseous disorders. All of these investigations are invasive (puncture) or requires specific conditions (intubation and ventilation). Saturation in fingers can show only poor capillary perfusion, but not gaseous metabolism. This technology allows earlier detection of dynamic gas disorders and better understand changes in patient conditions.
Contact Person

Julija Kravčenko


Kaunas University of Technology

Technology Category

  • Healthcare
  • Medical Devices

Technology Readiness Level


Oxygen uptake, Non-Invasive, Clinical Trials